Comparative Study of Three Brands of Antidiabetic Drug, Empagliflozin Available in Karachi, Pakistan

Comparative study of the antidiabetic drug

  • Khadija Aslam Student, Department of Pharmaceutical Chemistry, Jinnah University for Women.
  • Safila Naveed Dean Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Jinnah University for Women.
  • Fatima Qamar Lecturer Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Jinnah University for Women.
  • Halima Sadia Lecturer Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Jinnah University for Women.
  • Muhammad Ulusyar Khan Research Volunteer, Department of Medicine, Bolan Medical College, Quetta, Balochistan.
  • Tajala Aman MD, Department of Medicine, Bolan Medical College, Quetta, Balochistan.
Keywords: Empagliflozin, Physicochemical testing, Hardness, Thickness, Friability, Dissolution, Disintegration

Abstract

Empagliflozin is a newer oral antidiabetic drug that treats people who have type-II Diabetes Mellitus. Empagliflozin reduces the reabsorption of filtered glucose and increases urine glucose excretion. The objective of the study is to analyze the physiochemical equivalence of different brands of Empagliflozin available in Pakistan. Three different brands of Empagliflozin were evaluated for their physicochemical properties and cost-effectiveness. These brands were analyzed for different physicochemical tests for weight variation, hardness, friability, disintegration, and dissolution. All the brands had an average hardness of ≥2kg, which was suitable for an immediate-release tablet. All three brands had shown their friability variation within ±1% range specified by United State Pharmacopoeia (USP). The standard deviation was also calculated. All three brands showed good disintegration and dissolution profile which would aid in maximizing bioavailability and satisfying patient needs. The present findings suggest that almost all three brands of Empagliflozin that are available in Karachi meet the USP specification for quality control analysis.

Published
2023-04-26
How to Cite
Khadija Aslam, Safila Naveed, Fatima Qamar, Halima Sadia, Muhammad Ulusyar Khan, & Tajala Aman. (2023). Comparative Study of Three Brands of Antidiabetic Drug, Empagliflozin Available in Karachi, Pakistan. Journal of University Medical & Dental College, 14(2), 626-629. Retrieved from https://jumdc.com/index.php/jumdc/article/view/781
Section
Short Communication