The association of GSDMB rs7216389 polymorphism in childhood asthma

GSDMB rs7216389 and Childhood Asthma

Abstract

BACKGROUND AND OBJECTIVE:

Asthma is a chronic airway disease with increasing cases in children, differing from adult-onset asthma in terms of its triggers and outcomes. This study focuses on the rs7216389 variant of the GSDMB gene, exploring its role in airway inflammation and its clinical and genetic links to pediatric asthma, with implications for improved diagnosis and targeted treatment.

METHODOLOGY:

A case-control study spanning 18 months was carried out at CMH Lahore and Children’s Hospital, comprising 100 participants (50 with asthma and 50 healthy controls) aged 3–18 years. A genetic evaluation was conducted on blood specimens, and data analysis was executed using SPSS (v25.0). A p-value of less than 0.05 was considered significant. Ethical clearance was secured, and Informed consent was acquired.

RESULTS:

Research has found that the GASDERMIN B variant rs7216389 functions as a possible genetic risk factor for asthma because it links to severe asthma in children. The T allele of rs7216389 was significantly more frequent in asthmatic children (60%) than in controls (40%). This research acknowledges industry challenges in translating genetic discoveries into clinical practice, alongside descriptions of the therapeutic potential of genetic marker-based approaches. The research provides comprehensive information on healthcare expenses and is distinctive in its scope. Symptoms encountered in pediatric asthma patients can help better understand the full impact of the disease.

CONCLUSION:

The rs7216389 polymorphism in the GSDMB gene shows a significant association with childhood. asthma, underscoring its potential as a genetic marker for early risk identification and the development of personalized, targeted management strategies.