FREQUENCY OF FEBRILE NEUTROPENIA IN ELDERLY PATIENTS OF DIFFUSE LARGE B CELL LYMPHOMA RECEIVING MODIFIED DOSE CHOP REGIMEN OF CHEMOTHERAPY

  • Tanvir Ahmed
  • Tahir Mehmood
  • Shahbaz Ahmed
  • Muhammad Akram
  • Tehreem Fatima
Keywords: Diffuse large B cell lymphoma, Febrile neutropenia, Chemotherapy.

Abstract

Objective: To determine the frequency of febrile neutropenia in elderly patients of diffuse large B cell lymphoma receiving modified dose CHOP regimen of chemotherapy.

Material and Methods: This descriptive case series study was conducted on 140 Patients of diffuse large B-cell lymphoma at Department of Oncology Jinnah Hospital Lahore from May 2018 to October 2018. The patients aged 60-85 years and of either gender presenting with diffuse large B- cell lymphoma were included. Patients who have received any other treatment (chemotherapy, radiotherapy) prior to presentation and IHD were excluded. Selected patients received almost two- third dose of standard CHOP protocol, cyclophosphamide 750 mg/m2, doxorubicin 50 mg/m2, and vincristine 1.4 mg/m2 (maximum dose, 2.0 mg), all given intravenously on day 1, together with prednisone 60-100 mg/m2 PO on days 1-5, administered every 21 days. Frequency of febrile neutropenia was checked after cycle 1 of CHOP.

Results: Mean age was 70.6±5.6 years. Majority of the patients 81 (57.9%) were between 60 to 70 years of age. Out of the 140 patients, 83 (59.3%) were male and 57 (40.7%) were females with male to female ratio of 1.5:1. In this study, frequency of febrile neutropenia in elderly patients of diffuse large B cell lymphoma receiving modified dose CHOP regimen of chemotherapy was found in 80 (57.1%) patients.

Conclusion: This study concluded that the frequency of febrile neutropenia in elderly patients of Diffuse large B cell lymphoma receiving modified dose CHOP regimen of chemotherapy is quite high.

Author Biographies

Tanvir Ahmed

PGR, Department of Medical Oncology, AIMC/Jinnah Hospital Lahore.

Tahir Mehmood

Consultant Medical Oncologist, AIMC/Jinnah Hospital Lahore.

Shahbaz Ahmed

Associate Professor of Community Medicine, Independent Medical College Faisalabad

Muhammad Akram

Professor/HOD of Medical Oncology, AIMC/Jinnah Hospital Lahore.

Tehreem Fatima

Bs. Hons (Bio Chemistry), Research Assistant.

Published
2019-09-30