EFFICANCY OF GLIBENCLAMIDE FOR THE CONTROL OF GESTATIONAL DIABETES MELLITUS

  • Quddsia Tanveer Senior registrar Gynae Department Jinnah Hospital, Lahore
  • Anees Faima Senior registrar Gynae Department, Madina Teaching Hospital, UMDC, Faisalabad
  • Mubashra Naz Associate Professor, HOD Gynae, Madina Teaching Hospital, UMDC, Faisalabad
Keywords: Glibenclamide (glyburide), GDM, pregnancy

Abstract

ABSTRACT OBJECTIVE: To evaluate the efficacy of glibenclamide for control of gestational diabetes mellitus. STUDY DESIGN: An interventional: Quasi-experimental PLACE AND DURATION OF STUDY: Study was carried out at Obstetrics & Gynaecology department of Punjab Medical College and affiliated hospital, Faisalabad. The study duration was six months from Apr 2008 to Sep 2008. MATERIAL AND METHOD: Total of 50 Patients with gestational diabetes mellitus (GDM) were treated with oral glibenclamide. Achievement of satisfactory glycemic control, maternal hypoglycemia, complications like macrosomia, neonatal hypoglycemia, hypocalcaemia, neonatal polycythemia, gross neonatal congenital anomalies, transient tachypnea of new born (TTN) and need for admission in neonatal intensive care unit were main outcome measures. RESULTS: Of the 50 patients treated with glibenclamide, 40 (80%) achieved satisfactory glucose control. Maternal hypoglycemic events were found in 1 (2%), macrosomia in 07(14%), neonatal hypoglycemia in 05(10%), transient tachypnea of newborn in 4(8%) and need for admission to neonatology in 09 (18%) of cases. No case of gross congenital abnormality, neonatal hypocalcaemia and neonatal polycythemia observed. SCONCLUSION: In treatment of GDM, glibenclamide is successful in achieving good glycemic control.

Published
2015-03-03
How to Cite
Quddsia Tanveer, Anees Faima, & Mubashra Naz. (2015). EFFICANCY OF GLIBENCLAMIDE FOR THE CONTROL OF GESTATIONAL DIABETES MELLITUS. Journal of University Medical & Dental College, 6(2), 42-46. Retrieved from http://jumdc.com/index.php/jumdc/article/view/234
Section
Original Article