THE STUDY OF RELATIONSHIP BETWEEN THE SERUM LEVELS OF SEX HORMONE-BINDING GLOBULIN (SHBG) AND INCREASED INSULIN RESISTANCE IN THE MALE OFFSPRING OF TYPE 2 DIABETIC PARENTS, RISK OF DEVELOPMENT OF DIABETES IN THEIR OFFSPRING

  • Muhammad Ijaz Anwar Assistant Professor and HOD, Physiology, Nawaz Sharif Medical College, University of Gujrat, Research fellow, University of Health Sciences, Lahore
  • Zafar Hussain Professor and HOD Physiology, Punjab Medical College, Faisalabad
  • Aftab Ahmad Associate Professor, Sheikh Zaid MedicalCollege, Rahim Yar Khan
Keywords: Insulin resistance, Sex Hormone Binding Globulin (SHBG), Type 2 diabetes In treatment of GDM, glibenclamide is successful in achieving good glycemic control

Abstract

ABSTRACT: OBJECTIVE: To determine prospectively the relationship between insulin resistanceand sex hormone binding globulin(SHBG) in connection with risk ofdeveloping diabetes in male offspring oftype 2 diabetics. MATERIALS AND METHODS: This cross-sectional, analytical study included 80 subjects, 40 nondiabetic males (20-30years of age) of single type-2 diabeticparents and 40 age matched healthy male controls without a family history ofdiabetes. For each participant, detailedmedical history and clinical examinationwas performed. Fasting serum glucose,insulin, total testosterone, and sexhormone binding globulin weremeasured using standard kits. Bodymass index and insulin resistance indexwere calculated. For data analysis, groups of young adults(with and without family history of type-2 diabetes) were matched using validcriteria for significance of difference. RESULTS: Mean serum insulinconcentration, insulin resistance, body mass index (BMI) and waist circumference (WC) were significantlyhigher while sex hormone bindingglobulin levels were significantly low instudy subject. Insulin resistancecorrelated inversely with sex hormonebinding globulin. CONCLUSION: Low levels of sex hormonebinding globulin, hyperinsulinemia andinversecorrelation between sexhormone binding globulin and insulinresistance predict the possibledevelopment of diabetes mellitus inmale offspring of type 2 diabetics.

Published
2015-03-03
How to Cite
Muhammad Ijaz Anwar, Zafar Hussain, & Aftab Ahmad. (2015). THE STUDY OF RELATIONSHIP BETWEEN THE SERUM LEVELS OF SEX HORMONE-BINDING GLOBULIN (SHBG) AND INCREASED INSULIN RESISTANCE IN THE MALE OFFSPRING OF TYPE 2 DIABETIC PARENTS, RISK OF DEVELOPMENT OF DIABETES IN THEIR OFFSPRING. Journal of University Medical & Dental College, 6(2), 7-12. Retrieved from http://jumdc.com/index.php/jumdc/article/view/225
Section
Original Article