PROCEDURAL SEDATION AND ANALGESIA FOR ERCP: A COMPARATIVE STUDY OF THE PROPOFOL AND KETAMINE–PROPOFOL COMBINATION (KETOFOL)

Abstract

ABSTRACT:
OBJECTIVE: The aim of this study was to find a near ideal drug for procedural sedation and analgesia for patients undergoing ERCP.
STUDY DESIGN: A randomized control study was carried out for comparison.
SETTING & DURATION: This study was conducted at department of anaesthesia and intensive care, Madinah Teaching Hospital, Faisalabad from August 2014 to July 2015.
SAMPLE SIZE: The group under study consisted of 146 ASA I & II status patients undergoing ERCP.
METHODS: The patients were randomly divided into two groups A and B. Group A patients were to receive Propofol and Group B patients were to receive Ketamine-Propofol (Ketofol).
RESULTS: As compared to Propofol Group (group A), Ketofol group (group B) showed significant hemodynamic stability. The frequency of hypotension was 27.4% in group A as compared to 12.3% in group B. Respiratory drive was maintained in both groups. Requirement for post procedure analgesia was significant in group A being 16.4% as compared to 2.7% in group B. Time of onset and offset were also significantly shorter in group B.
CONCLUSION: It is concluded that Ketofol offers stable hemodynamics, adequate sedation and analgesia for patients undergoing ERCP. It also offers quick onset and offset of sedation. So it is a near ideal agent for procedural sedation and analgesia for ERCP.